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Intravenous drug use introduces pathogens like Staphylococcus aureus, leading to large vegetations and valvular destruction

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Groups of 20 male and 20 female CD-1 mice were given 0, 75, 125, or 250 mg/kg bw per day pyrene in corn oil by gavage for 13 weeks and then examined for changes in body weight, food consumption, mortality, clinical pathological manifestations in major organs and tissues, and changes in haematology and serum chemistry